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Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat T2DM have been gradually found to reduce the progression of AD in AD models

Results Each propensity-score matched group constituted 3424 patients, 45% women, 21% had a history of cardiovascular disease, and 13.9% were treated with sodium-glucose cotransporter-2 inhibitors at baseline

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While tirzepatide appears to provide greater weight loss than semaglutide in this population, head-to-head RCTs are not yet available.

Evaluate the benefits and concerns surrounding GLP-1 treatments