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GLP-1 drugs may reduce the release of dopamine in response to certain drugs, and reduce cravings for those drugs, the authors of the study wrote

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The development of therapeutics to enhance synaptic plasticity or confer synaptic neuroprotection represents an increasingly active area of early-phase drug development for AD (Cummings et al., 2023b)

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While there is potential mechanistic overlap with DPP-4 inhibitors or dual GLP/GIP receptor agonists we focus the current review on GLP-1RAs due to preponderance and availability of longer-term data, as well as the significantly higher market penetrance of this drug class