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While an early dose might temporarily increase appetite suppression, the most sustainable results come from following the prescribed weekly schedule and making healthy lifestyle choices
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Pregnancy and breastfeeding considerations are important
The specific population of neurons responsible for this effect is not clear as deletion of GLP-1r within the hypothalamus or even more specifically on pro-opiomelanocortin neurons with the arcuate nucleus of the hypothalamus also do not impact normal glucose regulation (18)
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