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Most patients notice appetite reduction within 1-2 weeks of starting treatment, with measurable weight loss typically beginning by week 4-6

[DOI] [PubMed] [Google Scholar] 48.Baggio LL, et al

Contrave Safety and Side Effects Common side effects of Contrave include dry mouth, changes in taste, nausea, vomiting, diarrhea, constipation, dizziness, headache, fatigue, flushing, sweating, uncontrolled shaking, and ringing in the ears