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Semaglutide showed the strongest signals, with 85% and 87% reductions in AUD and OUD odds, respectively

References 1.Wen S., Nguyen T., Gong M., Yuan X., Wang C., Jin J., Zhou L

Orforglipron looks aggressive, but even at 36 weeks its weight loss (-14.7%) offers little advantage over Semaglutide (-13.6%), and its discontinuation rate is significantly higher

Metabolic adaptation deepens as the dose reaches a more therapeutic range

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