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The GLP-1 resistance in diabetic conditions is thought to be caused by the downregulation of the GLP-1R caused by PKC overexpression and the decreased GLP-1 post-receptor anti-apoptotic signaling pathways caused by PKC overexpression [83]

Common Side Effects and How to Manage Them Gastrointestinal side effects are the most commonly reported adverse effects of semaglutide

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[103] [100] [104] Several other applications to sell generic versions have been made, but not yet approved, including by Aspen Pharmacare, Sandoz, Taro Pharmaceuticals and Teva Pharmaceuticals