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No changes in the atherosclerotic lesions size were detected, however, plaque vulnerability was reduced

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A reduction in caloric intake without structured dietary guidance can lead to unintended adverse effects on the gut microbiome

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Previous studies demonstrated that FXR knock-out mice models had reduced epithelial barrier integrity compared to wild-type mice, with a higher incidence of bacterial overgrowth

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The medication remains in Phase 3 clinical trials, with many additional trial readouts expected throughout 2026

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Aghaee-Bakhtiari, Tannaz Jamialahmadi, Amirhossein Sahebkar Journal of Clinical and Experimental Hepatology.2024

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