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Some individuals respond better to dual-pathway activation, particularly those with genetic evidence of reduced GLP1R sensitivity or strong FTO-mediated fat-storage predisposition

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The third embodiment of the present invention provides a process for the preparation of H-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-Val-Ser(tBu)-Ser(tBu)- Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(Boc)-Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)- Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-Resin, comprising