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Emerging effects of DPP-4 on bone metabolism include an inverse relationship between DPP-4 activity levels and bone mineral density, along with an increased risk of fractures

Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells that modulates glucose metabolism by controlling insulin excretion and glucagon secretion and inhibits gastric emptying leading to decreased food intake, thus limiting weight gain

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The cAMP-mediated PKA/extracellular signal-regulated kinase (ERK) pathway also contributes to the regulation of antioxidant enzymes, which in turn aids in the prevention of skin aging