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Clinical trials show that orforglipron can help people lose, on average, about 12% of their body weight

Cotadutide's modest results, in addition to its high rate of treatment discontinuation due to adverse events, mirror those from Ali et al

Pancreatitis One of the more severe, though less common, side effects of GLP-1 drugs is pancreatitis

For the average patient losing 28% of body weight with parallel improvements in blood pressure, lipids, and metabolic health, the net cardiovascular picture is strongly positive
