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In the SURPASS-4 trial, tirzepatide significantly decreased blood pressure, body weight, and HbA1c, and its dual-receptor agonism improved lipid profiles, increased insulin secretion, reduced inflammation, and promoted endothelial integrity (32)

By using chronic nitroglycerin injection-stimulated mouse model, it was observed that Liraglutide suppressed the nitroglycerin-induced upregulation of microglia in these mice, shortening both total and mean lengths of microglial processes and reduced nitroglycerin-induced upregulation of Iba-1, as well as, IL-1 and TNF- protein levels (Jing et al., 2021)

The new label, however, says the drug can be used to reduce the risks of heart disease

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promoting the differentiation of new neurons from precursor cells