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By marrying insulinotropic activities of GLP-1 and E2, we envisioned a synergism on islet -cells that express both ER and GLP-1 receptors (GLP-1R), while improving the therapeutic index of estrogen

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Nutrient supplementation with fiber, resistant starch, and unsaturated fats are the most studied supplements in both animal studies and small-scale human trialsoften showing increased circulating GLP-1 concentrations and associated metabolic improvements [260]

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