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Peppermint and spearmint reduce pressure on the lower esophageal sphincter, allowing stomach contents to flow back into the esophagus

The Role of the Clinical Examination in Patients With Heart Failure. JACC Heart Failure (2018): 543-551

51 One significant challenge is the high rate of gastrointestinal adverse events associated with these compounds, which may be related to their pharmacokinetic properties and direct gastrointestinal irritation

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