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Off-Label Use on the Rise Despite the promising data, many of these potential benefits fall outside the current FDA-approved uses, which include obesity, Type 2 diabetes, cardiovascular risk reduction, and more recently sleep apnea in some cases

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Furthermore, SIRT3 is an NAD(+)-dependent deacetylase which functions in conjunction with mitochondrial NAMPT to promote cell survival following genotoxic stress [31]

In a study published in September, researchers found that patients lost 5.1 percent of their weight on semaglutide (Ozympic) and 2.2 percent on liraglutide (Saxenda), on average