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The distribution of certain DA and 5-HT receptors in different parts of the brain suggests that the 5-HT system may have distinct contributions to ADHD

Serious adverse events were infrequent in the short term

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Volunteers were randomized to either receive a placebo or one of three varying doses of orforglipron, taken once a day (as is common with GLP-1 therapy, people gradually reached their maximum dose over time)