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Other Vitamin/Mineral Shortfalls: Calcium, magnesium, zinc, and copper are among other micronutrients that could become low if your diet is very limited

For patients where cardiovascular protection is the primary concern, both are reasonable choices, though semaglutides data may suggest greater benefit

Of these live births, 2 babies (1.8% of total) had congenital anomalies while 51 babies were born without reported birth defects

doi: 10.2337/db22-719-P

If phase 3 results remain positive, regulatory submissions may begin in 2026, meaning orforglipron could become available in late 2026 or 2027, depending on MHRA and NICE approval timelines