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"Many of its findings also have not been supported by more clinically and statistically robust studies." For example, a sub-study comparing these reports to objective iPhone health data suggested that participants might over-report their progress

Anc Sci Life (2009) 29:146

Thats a total of 38.4 million individuals of all ages

Such lipotoxicity induces cardiotoxic effects through bioactive sphingolipids like ceramides and diacylglycerols (DAGs) (82)
