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Subsequently, the two peptides secreted by the intestine were found to be involved in increased insulin secretion following an oral glucose load, GLP-1 and GIP

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The immunopathogenesis is driven by a predominance of T helper (Th)1-mediated immune responses, with elevated interferon- (IFN-) production and impaired function of regulatory T cells (Tregs), which normally restrain autoreactive lymphocytes [11,12]

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For many people, the most annoying side effects either fade or become much easier to manage over weeks to months

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