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Keywords: Glucagon-like peptide 1 receptor agonists, inflammation, inflammatory bowel disease, neurodegenerative disorder, nuclear factor-kappa B, obesity, type-2 diabetes Introduction Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RA), a category of medications frequently used to treat type 2 diabetes (T2D), comprise drugs such as exenatide, liraglutide, and semaglutide

WH, RS, RC, CL, RG, WT, JZ and QZ drafted and revised the manuscript

Mechanistically, they found that liraglutide inhibited the renal TNF- expression and NF-B as well as the MAPK pathway activation in these mice (Ye et al., 2019)

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Theyve also negotiated lower prices for several prescription drugs for Medicare enrollees, through a direct negotiation program created by a 2022 law