no weight loss on 2.5 tirzepatide 8 Week's in 2.5mg, and 45 lbs Gone : r/tirzepatidecompound Tirzepatide Injections for Medical Weight

Prior studies also did not examine concomitant medications that delay gastric emptying

Zepbound may be a particularly strong fit if you have not responded adequately to a single-receptor GLP-1 medication like Wegovy or Saxenda, if you have moderate-to-severe obstructive sleep apnea alongside obesity, or if your prescriber recommends starting with the most clinically effective option available

[Accessed 16th April 2026].

If you started or increased doses of these medications while on tirzepatide, they may be contributing to weight gain

The UK Chief Medical Officers' Physical Activity Guidelines and NICE recommend at least 150 minutes of moderate-intensity activity weekly for adults with type 2 diabetes