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observed that embryonic exposure of mice to metformin during the first half of pregnancy had a negative impact on the testicular size of young mice and number of Sertoli cells (at 16.5 dpc and 1 dpp) (61)

The metabolic protection of maintained muscle mass becomes the primary defense against the caloric surplus that drives weight regain

It works best when paired with strength training and a balanced protein intake

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Since then, shortages have ended, and the FDA says [archived link] the non-approved compounded versions can no longer be made and sold