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Inflammation in tissues or nerves can create a continuous background ache that affects quality of life

10.1371/journal.pone.0032008 39

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Quality of life during treatment matters significantly

In a prospective observational study involving 61 populations worldwide (approximately 1 million individuals aged 40-89 years) with an average follow-up of 12 years, [44] it was found that baseline office blood pressure ranging from 115/75 mmHg to 185/115 mmHg showed a continuous, independent, and direct positive correlation with the risks of stroke, coronary heart disease events, and cardiovascular mortality
