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GLP-1 medications do not cure obesity

Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice

Injecting into areas with adequate subcutaneous fat ensures the medication disperses properly rather than pooling in one spot or being absorbed too quickly

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These same populations face obstacles to receiving care including but not limited to challenges with transportation, lack of proximity to care, poor insurance coverage, food deserts and living in an environment not conducive to outdoor activity [214]