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Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis

Though both acute and continuous GLP-1 infusion produced significant reductions in food intake when compared to placebo ( P = 0.02 PSI and CSI), a statistically significant weight loss compared to placebo was only observed following PSI

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GLP-1 RAs regulate immune cell signaling, suppress proinflammatory cytokines (including tumor necrosis factor alpha (TNF), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)), enhance anti-inflammatory cytokines (interleukin-10- (IL-10)), and decrease reactive oxygen species

I thought of going back on it, she said, noting that because of her thyroid issues, her doctor advised against it