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However, native GLP-1 is always easily degraded by dipetidylpeptidase IV (DPP IV) to produce some N-terminally truncated metabolites in vivo, followed by rapid clearance (half-life is around 2 min), preventing its broad applications 8
In Phase 2 clinical trials, 88.8% of patients successfully tolerated treatment through 48 weeks

Japan Key Industry Developments January 2026: Japanese pharmaceutical companies accelerated regulatory approvals and launches of GLP-1 analogues for type 2 diabetes, supported by updated national diabetes management guidelines emphasizing weight management

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According to the STEP 1 trial, the average weight loss at 68 weeks was 14.9% of body weight [1] on the 2.4mg maintenance dose
