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The effects of GLP-1s increase postprandial insulin secretion from pancreatic -cells, suppress glucagon secretion from -cells, slow gastric emptying, and reduce appetite (Gross)

These issues can be addressed by future research that standardizes intervention and measurement protocols, broadens the study population, controls all confounding variables, and strengthens the studys design

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Reconstitution Process: Lyophilized peptides require reconstitution before use

In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms