tirzepatide super obesity bmi 60 and health‐related quality of life in adults with or overweight: Results from the SURMOUNT‐3 phase 3 randomized trial - Gibble - 2025 - Diabetes, Obesity and Metabolism Weight regain after the withdrawal
Description
We suggest it is reasonable for inpatients to restart GLP- 1 RAs when resuming their usual diet (Grade E)
The same dual action GLP-1 and GIP mechanism behind injectable tirzepatide, delivered as a daily oral tablet

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Both are administered as once-weekly subcutaneous injections using prefilled pens in the same dose range

Of the 783 patients who started ZEPBOUND at Week 0, 14.4% discontinued treatment before randomization at Week 36, and adverse events were the most common reason for discontinuation (6.8%)