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While GLP1R null mouse models have shown evidence of impaired long-term potentiation (LTP) and learning and memory deficits, GLP1R stimulation increases LTP and restores cognitive function in neurodegenerative mouse models

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On average, women gain about 1.5 pounds per year during the menopause transition (which can last 10 years )

They are generally not recommended for patients with a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), those who are pregnant or breastfeeding or planning pregnancy, patients with a known allergy to the medication, severe gastroparesis or serious digestive motility disorders, active pancreatitis or significant pancreatitis history, serious gallbladder disease, certain kidney conditions, or active eating disorder concerns

Available from: European Medicines Agency (EMA) (2023) Trulicity