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Metformin-induced increases in Gdf15 are important for suppressing appetite and promoting weight loss

And familiarity with the side-effect profiles of bisphosphonates, particularly atypical femoral fractures and osteonecrosis of the jaw, makes us better partners in the management of our patients' bone health

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Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates

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