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Likewise, the cardiovascular benefit of efpeglenatide was independent of GFR or the concomitant use of iSGLT-2, suggesting its additive and independent effect from the latter,85 as was also observed in the EXSCEL study.86 A recent meta-analysis of the 8 published cardiovascular safety clinical trials, and which included a total of 60
Releasing insulin
Diabetes Obes Metab (2014) 16(9):85060
Liraglutide is equipotent to GLP-1 in activating GLP-1R, with an EC50 of 61 pM for liraglutide vs
doi: 10.1007/s42000-018-0038-0 [DOI] [PubMed] [Google Scholar] 125
