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The search terms used included GLP-1 agonists, Glucagon-Like Peptide-1 Receptor Agonists, semaglutide, Ozempic, Wegovy, liraglutide, bone health, orthopedic surgery, arthroplasty, post-operative complications, complications, bone health, bone strength, osteogenesis, and bone metabolism. To ensure the relevance and quality of the studies, we established specific inclusion and exclusion criteria

Furthermore, GLP-1 RAs play a pivotal role in the alleviation of oxidative stress, the maintenance of mitochondrial homeostasis, and the inhibition of cell apoptosis and pyroptosis in models of ischemic cardiomyopathy [16]

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Cox proportional hazards models estimated hazard ratios comparing GLP-1RA users to non-users

The secondary endpoints were the percentage change in body weight from baseline to 48 weeks and the presence of weight reduction in 5%, 10%, and 15%