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237 The therapeutic effects of the amino salicylic acid class drug sulfalazine, 238 the antibiotics azithromycin and buspirone, 239 the opioid agonist human opiorphin, 240 the PDE5 inhibitor sildenafil 241 and many other commonly used clinical drugs in UC are attributed to the inhibition of the NFB pathway, which inhibits the expression of inflammatory cytokines and the infiltration of inflammatory cells, alleviating intestinal epithelial damage

However, a personalised approach is appropriate when: Symptoms arise Weight loss is substantial Baseline nutritional status is uncertain High-risk groups are present Oversight should be proportional, not automatic

Between breakfast and lunch, sip an additional 500 to 750ml

N Eng J Med 329(20):14561462

[DOI] [PubMed] [Google Scholar] 27.Jastreboff AM, Kushner RF