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Lofton adds that many prescribers may not feel comfortable prescribing these medications (They have not been properly trained or dont understand the complexity of overweight and obesity as chronic medical conditions, she says), making it difficult for patients to get the drug from their primary care physicians

"A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures"

1 Introduction to GLP-1 Glucagon-like peptide-1 (GLP-1) is a peptide hormone that is produced in the intestine and in multiple other sites that are known for their role in regulating glucose metabolism

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For example, the SELECT trial demonstrated that semaglutide reduced major cardiovascular events by 20% in overweight patients