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This is dangerous as it dramatically increases your risk of serious side effects, most notably seizures

Diabetes care portfolio including GLP-1 receptor agonist therapies

The amelioration of symptoms as assessed by the Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score, and improvements in exercise function seemed to be directly related to the magnitude of weight loss, such that greater improvement was observed with greater body weight loss (Borlaug et al

Obesity isnt just a therapeutic area, its a trillion-dollar gateway to treating diabetes, heart disease, and metabolic disorders
Therefore, dose adjustment is necessary in preclinical animal models