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Diabetes Obes Metab 2013;15:770-3.ArticlePubMed 113
Both formulations were extensively studied in clinical trial programs: s.c
Crisps and chocolate are among the most affected products
Advantage : Neither (tie) Weight Loss Efficacy# Orforglipron : ATTAIN-1 demonstrated 12.4% mean weight loss at 36 mg over 72 weeks (efficacy estimand)
The ventral tegmental area (VTA) and nucleus accumbens (NAc), key brain areas involved in the reinforcing effects of food and alcohol abuse, contain GLP-1 receptors, indicating central mediation of GLP-1 agonists 10
