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Start tirzepatide at 2.5 mg weekly immediately after the last dose of semaglutide 2.4 mg, without any washout period, then titrate monthly to 5 mg, 7.5 mg, 1...

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Glucagon increases blood glucose levels, particularly during fasting, and facilitates the mobilization of energy reserves.Synthetic agonists like semaglutide and tirzepatide are stable peptides that specifically activate the receptors of these hormones, amplifying their beneficial effects on glycemic control and weight management