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Distinguishing Treatment-Related Irritability from Other Causes Irritability during tirzepatide may stem from metabolic shifts, rapid appetite suppression, electrolyte changes, or genuine GLP-1 pathway effects on mood centers

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and later versions.Written informed consent was approved by the IRB and signed by all participants before enrolment

When semaglutide branded as Wegovy was first approved in 2021, weight loss was the only indication on its label

Careful medical monitoring is essential, and without meaningful changes to diet, increasing strength training, and lifestyle changes, the weight can quickly return once you stop the treatment leaving undesirable facial changes

References: Anderson T, Grady D