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Some patients taking Saxenda experience reduced fluid intake due to decreased appetite or may have increased fluid losses if experiencing diarrhoea or vomiting

The procedure for 24-h urine collection is described in our previous report (38)

Sarcopenia (age-related muscle loss) makes lean mass preservation during GLP-1 therapy even more critical

Dorsomedial hypothalamus (DMH) and preoptic area (POA) The DMH and POA are a functional complex of nuclei in the hypothalamus, which are involved in the regulation of feeding, drinking, body-weight, and circadian rhythms

FDA-approved Wegovy oral starts around $149/mo through manufacturer direct programs