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doi: 10.1007/s00125-023-05906-7

As we look to 2026, the story becomes one of defining firsts: the debut of oral GLP-1s, the first loss of exclusivity for a GLP-1 receptor antagonist, and landmark coverage decisions such as obesity medications entering Medicare formularies for obesity as a standalone indication

According to medical guidance: Any changes to your treatment plan, including discontinuation, should happen under provider supervision

And if you're looking for weight loss support yourself, your best first step is always to speak to your GP or registered healthcare professional who can point you in the right direction

This variability could have impacted the consistency of the results and the overall interpretation of gastrointestinal adverse events