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Limited human pregnancy data exists for these medications, which is why regulatory bodies and medical societies recommend discontinuation before conception

Follow-up Duration : While trials extend to 72 weeks or longer, the chronic nature of obesity requires decades-long, unavailable safety and efficacy data

Resting-state functional connectivity (rsFC) analysis will be conducted to assess correlations in blood-oxygen-level-dependent (BOLD) signal fluctuations between different brain regions in the absence of explicit tasks (1113)

The medications resist being degraded by DPP-4, which is the enzyme that breaks down naturally produced GLP-1 within a few minutes

Check vitamin B12 levels periodically with long-term use