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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: a replication study using reports to the World Health Organization pharmacovigilance database (VigiBase)

While this is a key research area, we propose that further investigations should verify whether GLP-1RAs may also affect cognitive and behavioral symptoms seen in psychosis, as suggested by their potential to influence neurobiological (for example, immune function) and neuropsychological (for example, reward) mechanisms that are known to be disrupted in psychotic illness

However, a cohort study using TriNetX found that sodium-glucose co-transporter 2 inhibitors also significantly decreased the risk of new glaucoma diagnosis compared with GLP-1 RAs (HR = .932)

If you are currently taking semaglutide or tirzepatide, speak with your doctor about a safe transition plan