glp-1 estrogen GLP-1RA and the possible skin aging | Endocrine Uterotrophic and mitogenic effects of

A key debate is whether lean mass decline in GLP-1-treated patients should be framed as an adverse event or as an expected physiological corollary of negative energy balance

Resistance training helps stimulate muscle tissue and may reduce muscle loss during weight reduction

The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with (65).In this cohort, obese individuals exhibited higher circulating levels of IL-17, supporting the concept that IL-17driven inflammation may be particularly prominent in this subgroup and may contribute to increased disease activity and reduced therapeutic responsiveness (66)

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