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In a clinical trial involving individuals with established cardiovascular disease, retatrutide reduced the risk of major adverse cardiovascular events, including heart attacks, strokes, and cardiovascular death

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In obese patients, acipimox can inhibit adipose tissue lipolysis by activating protein upregulated in macrophage by INF- (PUMA-G) (also known as the hydroxycarboxylic acid receptor 2 [HCA2] and GPR109a) receptors

mean eGFR was 65.0 (s.d
