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Sleep deprivation increases ghrelin (the hunger hormone), reduces leptin (the satiety hormone), increases insulin resistance, and promotes cortisol-driven visceral fat storage

Those with better blood sugar metabolism lose less weight

The full titration from 2.5 mg to 15 mg takes a minimum of 20 weeks

NICE recommends treatment only within specialist weight management services, typically for a maximum of 2 years, and only if non-surgical weight management interventions have been unsuccessful

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