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ACR Open Rheumatology (2025)

Beltre says many GLP-1 users experience fatigue, and B12 supports energy metabolism and nerve function, which can be affected by the meds and reduced food intake

While not always separately quantified in clinical trial data, bloatingcharacterized by a sensation of abdominal fullness, distension, or tightnessis recognized as part of the broader spectrum of gastrointestinal side effects associated with GLP-1 receptor agonists

There have also been supply constraints as off-label demand for weight-loss use exploded

Maintaining a moderate weight can help prevent a range of health conditions