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however most of these, such as the subgroups based on renal function in SUSTAIN-5 or subgroups based on A1C level at baseline in SUSTAIN-6, were not included as a stratification variable at randomization

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The mechanisms by which metformin causes diarrhea are multifaceted and involve several physiological processes: Increased Bile Acid Excretion Metformin increases the excretion of bile acids into the intestines

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Excess inventory ties up money that could be invested in other research needs, and even properly stored peptides gradually degrade