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Here, we report three cryo-electron microscopy structures of GLP-1R bound to (i) compound 2 (an ago-allosteric modulator)

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This inhibition is particularly important for two hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

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These assets aim to move beyond the current weekly injection paradigm, signalling a future where extended dosing intervals could become central to maintenance strategies [16].