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Overall, while semaglutide and tirzepatide remain effective options, mazdutide may offer enhanced metabolic benefits through its combination of appetite suppression, energy expenditure, and targeted fat loss, making it a promising candidate for patients with obesity complicated by metabolic disorders
doi:10.1210/en.2009-1272 Song Y, Zhou M, Cao Y, Qi J, Geng J, Liu X
In some cases, things are more severe
N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells
The clinical signal is now catching up to what the rodent data has been saying for a decade
