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Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice

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Key mesolimbic reward areas, like the ventral tegmental area (VTA) and nucleus accumbens (NAc), are innervated by the GLP-1 producing neurons in the NTS, potentially allowing hindbrain GLP-1 to modulate reward behaviour directly [44]

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As noted, the sequence similarity within the glucagon superfamily of peptides and the structural similarity within the secretin receptor family served as the molecular basis for engineering chimeric peptides with agonism at multiple receptors and with sizes comparable to the native peptides

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