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[91] You are encouraged to report negative side effects of prescription drugs to the FDA

Several 20242025 systematic reviews and meta-analyses have compiled the cross-trial safety data set (PMID 39318607, PMID 40291085, PMID 40728138)

Due to lack of stratified data by time points across studies, we were unable to perform a subgroup analysis based on duration of treatment, which limited our ability to evaluate time-dependent risk trends of gastrointestinal adverse events

As described by Lilly, retatrutide has a backbone chain of 39 alpha amino acids connected via an isopeptide bond to a second backbone chain that has two or more amino acids: gamma-glutamate, which is an alpha amino acid, and 8-amino-3,6-dioxaoctanoic acid (ADO), which is not